Protein Folding, Stability, and Solvation Structure in Osmolyte Solutions
نویسندگان
چکیده
منابع مشابه
Osmolyte solutions and protein folding
In this brief review we discuss the evolution of recent thought regarding the role and mechanism of osmolytes with respect to protein stability. Osmolytes are naturally occurring intracellular compounds that change the protein folding landscape. Contributions from experiments are considered in the context of current theory and simulation results.
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It is well-known that the typical protein’s three-dimensional structure is relatively unstable in harsh conditions. A practical approach to maintain the folded state and thus improve the stability and activity of proteins in unusual circumstances is to directly apply stabilizing substances such as osmolytes to the protein-containing solutions. Osmolytes as natural occurring organic molecules ty...
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L.R. Singh, N.K. Poddar, T.A. Dar, S. Rahman, R. Kumar and F. Ahmad* Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi-110007, India Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India 110025 School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, Jammu and Kashmir, India 185131 Department of ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2005
ISSN: 0006-3495
DOI: 10.1529/biophysj.105.067330